| Pair Name | Ursodiol, Sorafenib | ||
| Phytochemical Name | Ursodiol (PubChem CID: 31401 ) | ||
| Anticancer drug Name | Sorafenib (PubChem CID: 216239 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Ursodiol, Sorafenib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Phosphorylation | MAPK1 | hsa5594 |
| Down-regulation | Phosphorylation | STAT3 | hsa6774 | |
| In Vitro Model | Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 |
| Result | The present findings may represent a promising therapeutic strategy for patients with advanced hepatocellular carcinoma. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergistic effect of ursodeoxycholic acid on the antitumor activity of sorafenib in hepatocellular carcinoma cells via modulation of STAT3 and ERK. Int J Mol Med. 2018 Nov;42(5):2551-2559. doi: 10.3892/ijmm.2018.3807. | Click |
